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プロフィール

教授:Professor

所属及び連絡先

東京薬科大学生命科学部ゲノム病態医科学研究室

〒192-0392 東京都八王子市堀之内1432-1 研究3号館10階
Tel: 042-676-7214/Fax: 042-676-7249

Tokyo University of Pharmacy and Life Sciences.
Laboratory of Genome and Biosignals

1432-1 Horinouchi, Hachioji-city, Tokyo 192-0392, Japan
Tel: +81-42-676-7214/Fax: +81-42-676-7249

略歴

1978(昭和53)年 3月
岐阜薬科大学薬学部卒業
1978(昭和53)年 4月
慶応大学医学部薬局試験研究室
1985(昭和60)年 7月
東京都老人総合研究所薬理学部助手
1992(平成4)年 11月
東京大学医科学研究所癌生物学研究部助手
1999(平成11)年 7月
東京大学医科学研究所細胞生物化学研究部講師
2002(平成14)年 7月
東京大学医科学研究所腫瘍分子医学研究部助教授
2003(平成15)年 4月
東京薬科大学生命科学部ゲノム情報学研究室教授
2012(平成24)年 4月~
東京薬科大学生命科学部長

現在に至る

所属学会

  • 日本生化学会(副会長、評議員)
  • 日本脂質生化学会(理事)
  • 日本癌学会(評議員)
  • 日本細胞生物学会(評議員)

外部委員会委員等

  • 文部科学省国立大学法人評価委員会専門委員
  • 独立行政法人日本学術振興会グローバルCOEプログラム委員会専門委員
  • 独立行政法人科学技術振興機構「戦略的創造研究推進事業」領域アドバイザー
  • 独立行政法人医薬基盤研究所基盤的研究等外部評価委員
  • 日本私立学校振興・共済事業団学術振興資金選考委員会委員
  • 慶応義塾大学病院治験審査委員会学外委員
  • 神奈川県科学技術会議委員
  • 日本学術会議連携会員

受賞歴

1995(平成7)年 11月
日本癌学会奨励賞受賞
2003(平成15)年 5月
猿橋賞受賞
2006(平成18)年 10月
持田医学薬学振興財団持田記念学術賞

研究概要

  • 皮膚恒常性維持におけるイノシトールリン脂質代謝の役割の解明
  • リン脂質代謝を介した間葉系幹細胞の分化制御
  • 癌細胞の運動、浸潤、転移におけるイノシトールリン脂質シグナルの役割

主な研究業績

<英文原著論文>


  • ZIC5 drives melanoma aggressiveness by PDGFD-mediated activation of FAK and STAT3. Satow,R., Nakamura,T., Kato,C., Endo,M., Tamura,M., Batori,R., Tomura,S., Murayama,Y., Fukami,K. Cancer Res. 77.366-377 (2017)
  • PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. Hirabayashi, T., Anjo, T., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., Muramatsu, K., Fukami, K., Mun˜oz- Garcia, A., Brash, A R., Ikeda, K., Arita, M., Akiyama, M., Murakami, M., Nat Commun. 1;8:14609. (2017)
  • Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity. Kanemaru, K., Nakamura, Y., Totoki, K., Fukuyama, T., Shoji, M., Kaneko, H., Shiratori, K., Yoneda, A., Inoue, T., Iwakura, Y., Kabashima, Kenji., Fukami,K. Cell Death & Differ. 24, 1079-1090 (2017)
  • Phospholipase C δ1 negatively regulates autophagy in colorectal cancer cells. Shimozawa., M, Anzai., S, Satow., R, Fukami, K. Biochem Biophys Res Commun. Jul 8;488(4):578-583 (2017)
  • Identification of ZIC5 as a Survival Factor of Prostate and Colorectal Cancer Cells. Satow,R., Inagaki, S., Kato, C., Shimozawa, M., Fukami, K. Can. Sci. Dec;108(12):2405-2412 (2017)
  • Abe, Y., Rozqie, R., Matsumura, Y., Kawamura, T., Nakaki, R., Tsurutani, Y., Tanimura-Inagaki, K., Shiono, A., Magoori, K., Nakamura, K., Ogi, S., Kajimura, S., Kimura, H., Tanaka, T., Fukami, K., Osborne, T., Kodama, T., Hiroyuki Aburatani, Inagaki, T., and Sakai, J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis, Nature Commun. 6, 7052 (2015)
  • Kanemaru, K., Matsuyuki, A., Nakamura, Y., and Fukami, K. Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin 17 and interleukin 22 production in mice. Experimental Dermatology 10, 12691 (2015)
  • Ishida, S., Matsu-ura, T., Fukami, K., Michikawa, T., and Mikoshiba, K. Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PloS One. 9, 86410 (2014)
  • Yamaguchi, H., Takanashi, M., Yoshida, N., Ito, Y., Kamata, R., Fukami,K., Yanagihara, K., and Sakai, R. Saracatinib impairs the peritoneal dissemination of diffusetype gastric carcinoma cells resistant to Met and FGFR inhibitors. Cancer Sci. 10, 12387 (2014)
  • Nakamura, Y., Kanemaru, K., Kojima, R., Hashimoto, Y., Marunouchi, T., Oka, N., Ogura, T., Tanonaka, K., and Fukami, K. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Cell Death & Dis 5, 1215 (2014)
  • Satow, R., Hirano, T., Batori, R., Nakamura, T., Murayama, Y., and Fukami, K. Phospholipase C delta 1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells. Proc. Natl. Acad. Sci. USA. 111, 13505-13510 (2014)
  • Hirano, T., Satow, R., Kato, A., Tamura, M., Murayama, Y., Saya, H., Kojima, H., Nagano, T., Okabe, T., and Fukami, K. Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem Pharmacol. 86, 1419-29 (2013)
  • Kurokawa, H., Noda, H., Sugiyama, M., Sakaue-Sawano, A., Fukami, K., and Miyawaki, A. Software for precise tracking of cell proliferation. Biochem. Biophys. Res. Comm. 417, 1080-5 (2012)
  • Runkel, F., Hintze, M., Griesing, S., Michels, M., Blanck, B., Fukami, K., Guénet, J.L., and Franz, T. Alopecia in a viable Phospholipase C delta 1 and Phospholipase C delta 3 double Mutant. PLoS ONE 7, 39203 (2012)
  • Kanemaru, K., Nakamura, Y., Sato, K., Kojima, R., Takahashi, S., Yamaguchi, M., Ichinohe, M., Kiyonari, H., Shioi, G., Kabashima, K., Nakahigashi, K., Asargiri, M., Jamora, C., Yamaguchi, H., and Fukami, K. Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat. Commun. 3, 963 (2012)
  • Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M., Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J. Biol. Chem. 286, 11616-31(2011)
  • Kouchi, Z., Fujiwara, Y., Yamaguchi, H., Nakamura, Y., Fukami K., Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem. Biophys. Res. Comm. 408, 523-9 (2011)
  • Hirata, M., Suzuki, S., Ishii, R., Satow, R., Uchida, T., Kitazumi, T., Sasaki, T., Kitamura, T., Yamaguchi, H., Nakamura, Y., Fukami, K., Equally contributed. Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes 60, 1926-37 (2011)
  • Yamaguchi, H., Yoshida, S., Muroi, E., Yoshida, N., Kawamura, M., Kouchi, Z., Nakamura, Y., Sakai, R., Fukami. K., Phosphoinositide 3-kinase signaling mediated by p110α regulates invadopodia formation. J. Cell Biol. 193, 1275-88 (2011)
  • Okamoto, N., Yasukawa, M., Nguyen, C., Kasim, V., Maida, Y., Possemato, R., Shibata, T., Ligon, K. L., Fukami, K., Hahn, W. C., Masutomi, K., Maintenance of tumor initiating cells of defined genetic composition by a complex composed of nucleostemin. Proc. Natl. Acad. Sci.USA 108, 20388-93 (2011)
  • Yamaguchi, H., Yoshida, S., Muroi, E., Kawamura, M., Kouchi, Z., Nakamura, Y., Sakai, R., and Fukami, K. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ia are required for invadopodia formation in human breast cancer cells. Cancer Sci. 101. 1632-38 (2010)
  • Yamaguchi, H., Takeo, Y., Yoshida, S., Kouchi, Z., Nakamura, Y., Fukami , K. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res. 69. 8594-602 (2009)
  • Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S., and Miyawaki, A. Illuminating cell-cycle progression in the developing zebrafish embryo. Proc. Natl. Acad. Sci. USA 106, 20812–20817 (2009)
  • Nakamura, Y., Ichinohe, M., Hirata, M., Matsuura, H., Fujiwara, T., Igarashi, T., Nakahara, M., Yamaguchi, H., Yasugi, S., Takenawa T., and Fukami, K., Phospholipase C-d1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J. 22, 841-849 (2008)
  • Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., Imamura, T., Ogawa, M., Masai , H., and Miyawaki, A. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell, 132, 341-343 (2008)
  • Nakamura, Y., Hamada, Y., Fujiwara, T., Enomoto, H., Hiroe, T., Tanaka, S., Nose, M., Nakahara, M., Yoshida, N., Takenawa, T., and Fukami, K. Phospholipase Cd1 and d3 are essential in trophoblast for placental development. Mol. Cell. Biol. 25, 10979-10988 (2005)
  • Fukami, K., Yoshida, M., Inoue, T., Kurokawa, M., Fissore, A. R., Yoshida, N., Mikoshiba, K., and Takenawa, T. Phospholipase Cd4 is required for [Ca2+]i mobilization essential for acrosome reaction in sperm. J. Cell Biol. 161, 79-88 (2003)
  • Nakamura, Y., Fukami, K., Yu, H., Takenaka, K., Kataoka, Y., Shirakata, Y., Nishikawa, S., Hashimoto, K., Yoshida, N., and Takenawa, T., Phospholipase Cd1 is required for skin stem cell lineage commitment. EMBO J. 22, 2981-2991 (2003)
  • Takenaka, K., Fukami, K., Otsuki, M., Nakamura, Y., Kataoka, Y., Wada, M., Tsuji, K., Nishikawa, S., Yoshida, N., and Takenawa, T. The role of Phospholipase C-L2, a novel phospholipase C like protein that lacks lipase activity, in B cell receptor signaling Mol. Cell. Biol. 23. 7329-7338 (2003)
  • Fukuoka, M., Suetsugu, S., Miki, H., Fukami, K., Endo, T., and Takenawa, T. A novel N-WASP binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J. Cell Biol. 152, 471-482 (2001)
  • Fukami, K., Nakao, K., noue, T., Kataoka, Y., Kurokawa, M., Fissore, A. R., Nakamura, K., Katsuki, M., Mikoshiba, K., Yoshida, N., and Takenawa, T. Reqiurement of phospholipase Cd4 for the zona pellucida-induced acrosome reaction. Science. 292, 920-923 (2001)
  • Laux, T., Fukami, K. Thelen, M., Golub, T., Frey, D., and Caroni, P., GAP43, MARCKS, and CAP23 modulate PI(4,5)P2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149. 1455-1472 (2000)
  • Han, Jin-Kwan., Fukami, K., and Nuccitelli. R. Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres. J. Cell Biol. 116, 147-156 (1992)
  • Fukami, K., Furuhashi, K., Inagaki, M., Endo, T., Hatano, S., and Takenawa, T. Requirement of phosphatidylinositol 4,5-bisphosphate for a-actinin function. Nature 359. 150-152 (1992)
  • Fukami, K., Matsuoka, K., Nakanishi, O., Yamakawa, A., Kawai, S., and Takenawa, T. Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc. Natl. Acad. Sci. USA 85, 9057-9061 (1988)
  • Matsuoka, K., Fukami, K., Nakanishi, O., Kawai, S., and Takenawa, T. Mitogenesis in responce to PDGF and bombesin abolished by microinjection of antibody to PIP2. Science 239, 640-643 (1988)

<総説・著書等>


  • Regulation and physiological functions of mammalian phospholipase C. Nakamura, Y., Fukami,K. J. Biochem. 161.315-321(2017)
  • 中村由和、金丸佳織、深見希代子、「炎症性皮膚疾患とイノシトールリン脂質代謝系」実験医学増刊 脂質疾患学 なぜ “あぶら”の異常が病気を引き起こすのか?、羊土社、126-132 (2015)
  • 中村由和、深見希代子.「ホスホリパーゼC」 モデル動物利用マニュアル-脂質代謝異常と関連疾患. エル・アイ・シー、下巻 第1節 (2015)
  • Fukami, K., Nakamura, Y. The role of phospholipase C isozymes in cellular homeostasis. Phospholipases in Health and Disease 10,201-210 (2014)
  • 金丸佳織、中村由和、深見希代子 表皮におけるイノシトールリン脂質代謝の役割 生化学第86巻 第2号,255-258 (2014)
  • 中村由和、深見希代子.「ホスホリパーゼC」 モデル動物利用マニュアル-脂質代謝異常と関連疾患.下巻- エル・アイ・シー、印刷中
  • Nakamura. Y., Kanemaru, K., Fukami, K. Physiological functions of phospholipase Cδ1 and phospholipase. Cδ3. Adv. Biol. Regul. 53. 356-62 (2013).
  • 深見希代子、中村由和 ホスホリパーゼC (PLC)による恒常性維持機構とその破綻がもたらす疾病 医学のあゆみ 248 (13) 1051-1058 (2013).
  • Høye, A. M., Couchman, J. R., Wewer, U. M., Fukami,K., Yoneda, A., The newcomer in the integrin family: Integrin α9 in biology and cancer, Adv. Biol. Reg. in press
  • Fukami, K., Inanobe, S., Kanemaru, K., Nakamura, Y., Phospholipase C is a key enzyme regulating intracellular calcium and modulating balance of phosphoinositides. Progress in Lipid Research 49, 366-377 (2010).
  • 中村由和、深見希代子 遺伝子改変マウスの表現型より示されるホスホリパーゼCの生理的役割 実験医学増刊 分子から個体へと深化する脂質生物学 Vol.28 No.20 126-132 (2010).
  • Nakamura, Y., Fukami, K., Roles of phospholipase C isozymes in organogenesis and embryonic development. Physiology. 24, 332-41 (2009).
  • Fukami, K., Ichinohe, M., Hirata, M., Nakamura, Y. Physiological functions of Phospholipase C delta-type. Advan. Enzyme Regul. 48, 261-73 (2008).
  • Suh, P. G., Park, J. I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.,and Ryu, S. H., Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41, 415-34 (2008).