ページトップへ

プロフィール

教授:Professor

所属及び連絡先

東京薬科大学生命科学部ゲノム病態医科学研究室

〒192-0392 東京都八王子市堀之内1432-1 研究3号館10階
Tel: 042-676-7214/Fax: 042-676-7249

Tokyo University of Pharmacy and Life Sciences.
Laboratory of Genome and Biosignals

1432-1 Horinouchi, Hachioji-city, Tokyo 192-0392, Japan
Tel: +81-42-676-7214/Fax: +81-42-676-7249

略歴

1978(昭和53)年 3月
岐阜薬科大学薬学部卒業
1978(昭和53)年 4月
慶応大学医学部薬局試験研究室
1985(昭和60)年 7月
東京都老人総合研究所薬理学部助手
1992(平成4)年 11月
東京大学医科学研究所癌生物学研究部助手
1999(平成11)年 7月
東京大学医科学研究所細胞生物化学研究部講師
2002(平成14)年 7月
東京大学医科学研究所腫瘍分子医学研究部助教授
2003(平成15)年 4月
東京薬科大学生命科学部ゲノム情報学研究室教授
2012(平成24)年 4月~
東京薬科大学生命科学部長

現在に至る

所属学会

  • 日本生化学会(副会長、評議員)
  • 日本脂質生化学会(理事)
  • 日本癌学会(評議員)
  • 日本細胞生物学会(評議員)

外部委員会委員等

  • 文部科学省国立大学法人評価委員会専門委員
  • 独立行政法人日本学術振興会グローバルCOEプログラム委員会専門委員
  • 独立行政法人科学技術振興機構「戦略的創造研究推進事業」領域アドバイザー
  • 独立行政法人医薬基盤研究所基盤的研究等外部評価委員
  • 日本私立学校振興・共済事業団学術振興資金選考委員会委員
  • 慶応義塾大学病院治験審査委員会学外委員
  • 神奈川県科学技術会議委員
  • 日本学術会議連携会員

受賞歴

1995(平成7)年 11月
日本癌学会奨励賞受賞
2003(平成15)年 5月
猿橋賞受賞
2006(平成18)年 10月
持田医学薬学振興財団持田記念学術賞

研究概要

  • 皮膚恒常性維持におけるイノシトールリン脂質代謝の役割の解明
  • リン脂質代謝を介した間葉系幹細胞の分化制御
  • 癌細胞の運動、浸潤、転移におけるイノシトールリン脂質シグナルの役割

主な研究業績

<英文原著論文>


  • Abe, Y., Rozqie, R., Matsumura, Y., Kawamura, T., Nakaki, R., Tsurutani, Y., Tanimura-Inagaki, K., Shiono, A., Magoori, K., Nakamura, K., Ogi, S., Kajimura, S., Kimura, H., Tanaka, T., Fukami, K., Osborne, T., Kodama, T., Hiroyuki Aburatani, Inagaki, T., and Sakai, J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis, Nature Commun. 6, 7052 (2015)
  • Kanemaru, K., Matsuyuki, A., Nakamura, Y., and Fukami, K. Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin 17 and interleukin 22 production in mice. Experimental Dermatology 10, 12691 (2015)
  • Ishida, S., Matsu-ura, T., Fukami, K., Michikawa, T., and Mikoshiba, K. Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PloS One. 9, 86410 (2014)
  • Yamaguchi, H., Takanashi, M., Yoshida, N., Ito, Y., Kamata, R., Fukami,K., Yanagihara, K., and Sakai, R. Saracatinib impairs the peritoneal dissemination of diffusetype gastric carcinoma cells resistant to Met and FGFR inhibitors. Cancer Sci. 10, 12387 (2014)
  • Nakamura, Y., Kanemaru, K., Kojima, R., Hashimoto, Y., Marunouchi, T., Oka, N., Ogura, T., Tanonaka, K., and Fukami, K. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Cell Death & Dis 5, 1215 (2014)
  • Satow, R., Hirano, T., Batori, R., Nakamura, T., Murayama, Y., and Fukami, K. Phospholipase C delta 1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells. Proc. Natl. Acad. Sci. USA. 111, 13505-13510 (2014)
  • Hirano, T., Satow, R., Kato, A., Tamura, M., Murayama, Y., Saya, H., Kojima, H., Nagano, T., Okabe, T., and Fukami, K. Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem Pharmacol. 86, 1419-29 (2013)
  • Kurokawa, H., Noda, H., Sugiyama, M., Sakaue-Sawano, A., Fukami, K., and Miyawaki, A. Software for precise tracking of cell proliferation. Biochem. Biophys. Res. Comm. 417, 1080-5 (2012)
  • Runkel, F., Hintze, M., Griesing, S., Michels, M., Blanck, B., Fukami, K., Guénet, J.L., and Franz, T. Alopecia in a viable Phospholipase C delta 1 and Phospholipase C delta 3 double Mutant. PLoS ONE 7, 39203 (2012)
  • Kanemaru, K., Nakamura, Y., Sato, K., Kojima, R., Takahashi, S., Yamaguchi, M., Ichinohe, M., Kiyonari, H., Shioi, G., Kabashima, K., Nakahigashi, K., Asargiri, M., Jamora, C., Yamaguchi, H., and Fukami, K. Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat. Commun. 3, 963 (2012)
  • Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M., Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J. Biol. Chem. 286, 11616-31(2011)
  • Kouchi, Z., Fujiwara, Y., Yamaguchi, H., Nakamura, Y., Fukami K., Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem. Biophys. Res. Comm. 408, 523-9 (2011)
  • Hirata, M., Suzuki, S., Ishii, R., Satow, R., Uchida, T., Kitazumi, T., Sasaki, T., Kitamura, T., Yamaguchi, H., Nakamura, Y., Fukami, K., Equally contributed. Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes 60, 1926-37 (2011)
  • Yamaguchi, H., Yoshida, S., Muroi, E., Yoshida, N., Kawamura, M., Kouchi, Z., Nakamura, Y., Sakai, R., Fukami. K., Phosphoinositide 3-kinase signaling mediated by p110α regulates invadopodia formation. J. Cell Biol. 193, 1275-88 (2011)
  • Okamoto, N., Yasukawa, M., Nguyen, C., Kasim, V., Maida, Y., Possemato, R., Shibata, T., Ligon, K. L., Fukami, K., Hahn, W. C., Masutomi, K., Maintenance of tumor initiating cells of defined genetic composition by a complex composed of nucleostemin. Proc. Natl. Acad. Sci.USA 108, 20388-93 (2011)
  • Yamaguchi, H., Yoshida, S., Muroi, E., Kawamura, M., Kouchi, Z., Nakamura, Y., Sakai, R., and Fukami, K. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ia are required for invadopodia formation in human breast cancer cells. Cancer Sci. 101. 1632-38 (2010)
  • Yamaguchi, H., Takeo, Y., Yoshida, S., Kouchi, Z., Nakamura, Y., Fukami , K. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res. 69. 8594-602 (2009)
  • Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S., and Miyawaki, A. Illuminating cell-cycle progression in the developing zebrafish embryo. Proc. Natl. Acad. Sci. USA 106, 20812–20817 (2009)
  • Nakamura, Y., Ichinohe, M., Hirata, M., Matsuura, H., Fujiwara, T., Igarashi, T., Nakahara, M., Yamaguchi, H., Yasugi, S., Takenawa T., and Fukami, K., Phospholipase C-d1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J. 22, 841-849 (2008)
  • Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., Imamura, T., Ogawa, M., Masai , H., and Miyawaki, A. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell, 132, 341-343 (2008)
  • Nakamura, Y., Hamada, Y., Fujiwara, T., Enomoto, H., Hiroe, T., Tanaka, S., Nose, M., Nakahara, M., Yoshida, N., Takenawa, T., and Fukami, K. Phospholipase Cd1 and d3 are essential in trophoblast for placental development. Mol. Cell. Biol. 25, 10979-10988 (2005)
  • Fukami, K., Yoshida, M., Inoue, T., Kurokawa, M., Fissore, A. R., Yoshida, N., Mikoshiba, K., and Takenawa, T. Phospholipase Cd4 is required for [Ca2+]i mobilization essential for acrosome reaction in sperm. J. Cell Biol. 161, 79-88 (2003)
  • Nakamura, Y., Fukami, K., Yu, H., Takenaka, K., Kataoka, Y., Shirakata, Y., Nishikawa, S., Hashimoto, K., Yoshida, N., and Takenawa, T., Phospholipase Cd1 is required for skin stem cell lineage commitment. EMBO J. 22, 2981-2991 (2003)
  • Takenaka, K., Fukami, K., Otsuki, M., Nakamura, Y., Kataoka, Y., Wada, M., Tsuji, K., Nishikawa, S., Yoshida, N., and Takenawa, T. The role of Phospholipase C-L2, a novel phospholipase C like protein that lacks lipase activity, in B cell receptor signaling Mol. Cell. Biol. 23. 7329-7338 (2003)
  • Fukuoka, M., Suetsugu, S., Miki, H., Fukami, K., Endo, T., and Takenawa, T. A novel N-WASP binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J. Cell Biol. 152, 471-482 (2001)
  • Fukami, K., Nakao, K., noue, T., Kataoka, Y., Kurokawa, M., Fissore, A. R., Nakamura, K., Katsuki, M., Mikoshiba, K., Yoshida, N., and Takenawa, T. Reqiurement of phospholipase Cd4 for the zona pellucida-induced acrosome reaction. Science. 292, 920-923 (2001)
  • Laux, T., Fukami, K. Thelen, M., Golub, T., Frey, D., and Caroni, P., GAP43, MARCKS, and CAP23 modulate PI(4,5)P2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149. 1455-1472 (2000)
  • Han, Jin-Kwan., Fukami, K., and Nuccitelli. R. Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres. J. Cell Biol. 116, 147-156 (1992)
  • Fukami, K., Furuhashi, K., Inagaki, M., Endo, T., Hatano, S., and Takenawa, T. Requirement of phosphatidylinositol 4,5-bisphosphate for a-actinin function. Nature 359. 150-152 (1992)
  • Fukami, K., Matsuoka, K., Nakanishi, O., Yamakawa, A., Kawai, S., and Takenawa, T. Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc. Natl. Acad. Sci. USA 85, 9057-9061 (1988)
  • Matsuoka, K., Fukami, K., Nakanishi, O., Kawai, S., and Takenawa, T. Mitogenesis in responce to PDGF and bombesin abolished by microinjection of antibody to PIP2. Science 239, 640-643 (1988)

<総説・著書等>


  • Fukami, K., Nakamura, Y. The role of phospholipase C isozymes in cellular homeostasis. Phospholipases in Health and Disease 10,201-210 (2014)
  • 金丸佳織、中村由和、深見希代子 表皮におけるイノシトールリン脂質代謝の役割 生化学第86巻 第2号,255-258 (2014)
  • 中村由和、深見希代子.「ホスホリパーゼC」 モデル動物利用マニュアル-脂質代謝異常と関連疾患.下巻- エル・アイ・シー、印刷中
  • Nakamura. Y., Kanemaru, K., Fukami, K. Physiological functions of phospholipase Cδ1 and phospholipase. Cδ3. Adv. Biol. Regul. 53. 356-62 (2013).
  • 深見希代子、中村由和 ホスホリパーゼC (PLC)による恒常性維持機構とその破綻がもたらす疾病 医学のあゆみ 248 (13) 1051-1058 (2013).
  • Høye, A. M., Couchman, J. R., Wewer, U. M., Fukami,K., Yoneda, A., The newcomer in the integrin family: Integrin α9 in biology and cancer, Adv. Biol. Reg. in press
  • Fukami, K., Inanobe, S., Kanemaru, K., Nakamura, Y., Phospholipase C is a key enzyme regulating intracellular calcium and modulating balance of phosphoinositides. Progress in Lipid Research 49, 366-377 (2010).
  • 中村由和、深見希代子 遺伝子改変マウスの表現型より示されるホスホリパーゼCの生理的役割 実験医学増刊 分子から個体へと深化する脂質生物学 Vol.28 No.20 126-132 (2010).
  • Nakamura, Y., Fukami, K., Roles of phospholipase C isozymes in organogenesis and embryonic development. Physiology. 24, 332-41 (2009).
  • Fukami, K., Ichinohe, M., Hirata, M., Nakamura, Y. Physiological functions of Phospholipase C delta-type. Advan. Enzyme Regul. 48, 261-73 (2008).
  • Suh, P. G., Park, J. I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.,and Ryu, S. H., Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41, 415-34 (2008).