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業績

  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • ~2010

2017

主な原著論文

  • ZIC5 drives melanoma aggressiveness by PDGFD-mediated activation of FAK and STAT3. Satow,R., Nakamura,T., Kato,C., Endo,M., Tamura,M., Batori,R., Tomura,S., Murayama,Y., Fukami,K. Cancer Res. 77.366-377 (2017)
  • PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. Hirabayashi, T., Anjo, T., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., Muramatsu, K., Fukami, K., Mun˜oz- Garcia, A., Brash, A R., Ikeda, K., Arita, M., Akiyama, M., Murakami, M., Nat Commun. 1;8:14609. (2017)
  • Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity. Kanemaru, K., Nakamura, Y., Totoki, K., Fukuyama, T., Shoji, M., Kaneko, H., Shiratori, K., Yoneda, A., Inoue, T., Iwakura, Y., Kabashima, Kenji., Fukami,K. Cell Death & Differ. 24, 1079-1090
  • Phospholipase C δ1 negatively regulates autophagy in colorectal cancer cells. Shimozawa M, Anzai S, Satow R, Fukami K.Biochem Biophys Res Commun. 2017 in press

総説・著書など

  • 中村由和 「総説:ホスホリパーゼCの活性化機構と生理機能」、生化学、日本生化学会 日本生化学会奨励賞受賞総説 89.189-198(2017)
  • Regulation and physiological functions of mammalian phospholipase C. Nakamura, Y., Fukami,K. J. Biochem. 161.315-321(2017)

2016

主な原著論文

  • Høye, AM., Couchman, JR., Wewer, UM., and Yoneda, A. The phosphorylation and distribution of cortactin downstream of integrin α9β1 affects cancer cell behaviour. Sci. Rep.6. 28529 (2016)
  • Kudo, K., Uchida, T., Sawada, M., Nakamura, Y., Yoneda, A., Fukami, K. hospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.Adv. Biol. Regul.61. 68-79 (2016)

総説・著書など

  • Gomes, A. M., Sinkeviciute, D., Multhaupt, H. A. B., Yoneda, A., Couchman, J. R. Syndecan heparan sulfate proteoglycans: regulation, signaling and impact on tumor biology. シンデカンヘパラン硫酸プロテオグリカン:制御、シグナリング、癌生物学への影響 Trends Glycosci. Glycotechnol. 28, E79-E90, (2016)

2015

主な原著論文

  • Matsumura, Y., Yoshida,A., Nakaki,R., Kano,Y., Kimura,H., Tanaka,T., Inagaki,T., Shinkai,Y., Fukami,K., Doi,T., Osborne, T. F., Kodama, T. Aburatani,H., and Sakai, J. H3K4/H3K9me3 bivalent chromatin domains targeted by lineage-specific DNA methylation pauses adipocyte differentiation. Mol Cell. 60, 584-96 (2015)
  • Inagaki, T., Iwasaki, S., Matsumura, Y., Kawamura, T., Tanaka, T., Abe, Y., Yamasaki, A., Tsurutani, Y., Yoshida, A., Chikaoka, Y., Nakamura, K., Magoori, K., Nakaki, R., Osborne., F. T, Fukami, K., Aburatani, H., Kodama, T., and Sakai, J. The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis. J. Biol. Chem. 290, 4163-77 (2015)
  • Abe, Y., Rozqie, R., Matsumura, Y., Kawamura, T., Nakaki, R., Tsurutani, Y., Tanimura-Inagaki, K., Shiono, A., Magoori, K., Nakamura, K., Ogi, S., Kajimura, S., Kimura, H., Tanaka, T., Fukami, K., Osborne, T., Kodama, T., Hiroyuki Aburatani, Inagaki, T., and Sakai, J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis, Nature Commun. 6, 7052 (2015)
  • Kanemaru, K., Matsuyuki, A., Nakamura, Y., and Fukami, K. Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin 17 and interleukin 22 production in mice. Exp. Dermatol 24, 436-442(2015)

総説・著書など

  • 中村由和、金丸佳織、深見希代子、「炎症性皮膚疾患とイノシトールリン脂質代謝系」実験医学増刊 脂質疾患学 なぜ “あぶら”の異常が病気を引き起こすのか?、羊土社、126-132 (2015)
  • Yoneda, A. Fibronectin Matrix Assembly and Its Significant Role in CancerProgression and Treatment. フィブロネクチンマトリックス形成とがんにおけるその重要性. Trends in Glycoscience and Glycotechnology, Minireview .27,89-98 (2015)
  • 中村由和、深見希代子.「ホスホリパーゼC」 モデル動物利用マニュアル-脂質代謝異常と関連疾患. エル・アイ・シー、下巻 第1節 (2015)

2014

主な原著論文

  • Nakamura, Y., Kanemaru, K., Kojima, R., Hashimoto, Y., Marunouchi, T., Oka, N., Ogura, T., Tanonaka, K., and Fukami, K. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Cell Death & Dis 5,1215 (2014)
  • Ishida, S., Matsu-ura, T., Fukami, K., Michikawa, T., and Mikoshiba, K. Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PloS One. 9, 86410 (2014)
  • Yamaguchi, H., Yoshida, N., Takanashi, M., Ito, Y., Fukami, K., Yanagihara, K., Yashiro, M., and Sakai, R. Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells. PloS One. 9, 85485 (2014)
  • Yamaguchi, H., Takanashi, M., Yoshida, N., Ito, Y., Kamata, R., Fukami,K., Yanagihara, K., and Sakai, R. Saracatinib impairs the peritoneal dissemination of diffusetype gastric carcinoma cells resistant to Met and FGFR inhibitors. Cancer Sci. 10,12387 (2014)
  • Kobayashi, E., Satow, R., Ono, M., Masuda, M., Honda, K., Sakuma, T., Kawai, A., Morioka, H., Toyama, Y., and Yamada, T. MicroRNA expression and functional profiles of osteosarcoma. Oncology 86, 94-103 (2014)
  • Satow, R., Hirano, T., Batori, R., Nakamura, T., Murayama, Y., and Fukami, K. Phospholipase C delta 1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 111, 13505-13510 (2014)

総説・著書など

  • Fukami, K., Nakamura, Y. The role of phospholipase C isozymes in cellular homeostasis. Phospholipases in Health and Disease 10,201-210 (2014)
  • 金丸佳織、中村由和、深見希代子 表皮におけるイノシトールリン脂質代謝の役割 生化学第86巻 第2号,255-258 (2014)

2013

主な原著論文

  • *Hirano, T., *Satow, R., Kato, A., Tamura, M., Murayama, Y., Saya, H., Kojima, H., Nagano, T., Okabe, T., and Fukami, K. Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem. Pharmacol. 86, 1419-29 (2013). (*equally contribution)
  • Lukacs, V., Yudin Y, Hammond, G. R., Sharma, E., Fukami, K., and Rohacs, T. Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J. Neurosci. 33,11451-63 (2013).
  • Staats, KA., Van, H. L., Jones, A. R., Bento, A. A., Van, H. A., Shatunov, A., Simpson. C.L., Lemmens. R., Jaspers. T., Fukami, K., Nakamura, Y., Brown, RH. Jr, Van, D. P., Liston, A., Robberecht, W., Al-Chalabi. A., and Van, D. B.L. Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice. Neurobiol. Dis. 60,11-7 (2013).
  • Morgan-Fisher, M., Couchman, J.R., and Yoneda, A. Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. J. Biol. Chem. 288.31229-31240 (2013).

総説・著書など

  • Nakamura. Y., Kanemaru, K., Fukami, K. Physiological functions of phospholipase Cδ1 and phospholipase. Cδ3. Adv. Biol. Regul. 53. 356-62 (2013).
  • 深見希代子、中村由和 ホスホリパーゼC (PLC)による恒常性維持機構とその破綻がもたらす疾病 医学のあゆみ 248 (13) 1051-1058 (2013).
  • Morgan-Fisher, M., Wewer, U. M., and Yoneda, A. Regulation of ROCK activity in cancer. J. Histochem. Cytochem. 61, 185-198,(2013).

2012

主な原著論文

  • Kanemaru, K., Nakamura, Y., Sato, K., Kojima, R., Takahashi, S., Yamaguchi, M., Ichinohe, M., Kiyonari, H., Shioi, G., Kabashima, K., Nakahigashi, K., Asargiri, M., Jamora, C., Yamaguchi, H., and Fukami, K. K. Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat. Commun. 3, 963 (2012).
  • Satow, R., Shitashige, M., Jigami, T., Fukami, K., Honda, K., Kitabayashi, I., and Yamada., T. β-catenin antagonizes PML tumor suppressor function by inhibiting SUMOylation and nuclear body formation. Gastroenterology 142, 572-81 (2012).
  • Kurokawa, H., Noda, H., Sugiyama, M., Sakaue-Sawano, A., Fukami, K., and Miyawaki, A. Software for precise tracking of cell proliferation. Biochem. Biophys. Res. Comm. 417, 1080-5 (2012).
  • Yoneda, A., Morgan-Fisher, M., Wait, R., Couchman, J. R., and Wewer, U. M. A CRMP-2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol. Cell. Biol. 32,1788-804 (2012).
  • Yunokawa, M., Koizumi, F., Kitamura, Y., Katanasaka, Y., Okamoto, N., Kodaira, M., Yonemori, K., Shimizu, C., Ando, M., Masutomi, K., Yoshida, T., Fujiwara, Y., and Tamura, K. Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells. Cancer Sci, 103, 1665-71(2012).
  • Runkel, F., Hintze, M., Griesing, S., Michels, M., Blanck, B., Fukami, K., Guénet, J.L., and Franz, T. Alopecia in a viable Phospholipase C delta 1 and Phospholipase C delta 3 double Mutant. PLoS ONE 7, e39203 (2012).
  • Ard, R., Mulatz, K., Abramovici, H., Maillet, J.C., Fottinger, A., Foley, T., Byham, M., Iqbal, T.A., Yoneda, A., Couchman, J.R., Parks, R.J., and Gee, S.H. Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism. Mol. Biol. Cell 23, 4008-4019, 2012.

総説・著書など

  • Yoneda, A., Lendorf, M. E., Couchman, J. R., and Multhaupt, H. A. Breast and ovarian cancers: a survey and possible roles for the cell surface haparan sulfate proteoglycans. J. Histochem. Cytochem. 60, 9-21,(2012).
  • Høye, A. M., Couchman, J. R., Wewer, U. M., Fukami, K., and Yoneda., A. The newcomer in the integrin family: Integrin α9 in biology and cancer. Adv. Biol. Reg. 52, 326-39,(2012).

2011

主な原著論文

  • Yamaguchi, H., Yoshida, S., Muroi, E., Yoshida, N., Kawamura, M., Kouchi, Z., Nakamura, Y., Sakai, R., Fukami. K., Phosphoinositide 3-kinase signaling mediated by p110α regulates invadopodia formation. J. Cell Biol. 193, 1275-88 (2011).
  • Hirata, M (*)., Suzuki, S (*)., Ishii, R (*)., Satow, R., Uchida, T., Kitazumi, T., Sasaki, T., Kitamura, T., Yamaguchi, H., Nakamura, Y., Fukami, K., (*) Equally contributed. Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes 60, 1926-37 (2011).
  • Kouchi, Z., Fujiwara, Y., Yamaguchi, H., Nakamura, Y., Fukami K., Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem. Biophys. Res. Comm. 408, 523-9 (2011).
  • Kouchi, Z(*)., Igarashi, T(*)., Shibayama, N(*). , Inanobe, S., Sakurai, K., Yamaguchi, H., Fukuda, T., Yanagi, S., Nakamura, Y., Fukami, K., (*) Equally contributed. Phospholipase Cδ3 regulates RhoA/Rho kinase signaling and neurite outgrowth. J. Biol. Chem. 86, 8459-71 (2011).
  • Sakurai, K., Hirata, M., Yamaguchi, H., Nakamura, Y., Fukami, K., Phospholipase Cδ3 is a novel binding partner of Myosin VI and functions as anchoring of Myosin VI on plasma membrane. Advan. Enzyme Regul., 51, 171–181 (2011).
  • Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M., Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J. Biol. Chem. 286, 11616-31(2011).
  • Hama, H., Kurokawa, H., Kawano, H., Ando, R., Shimogori, T., Noda, H., Fukami, K., Sakaue-Sawano, A., Miyawaki, A., Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain Nature Neuroscience 14, 1481-8 (2011).
  • Tsutsumi, K., Matsuda, M., Kotani, M., Murakami, A., Takahashi, I., Terada, T., Kanematsu, T., Fukami, K., Takenawa, T., Jimi, E., Hirata, M., Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation J. Biol. Chem. 286, 31032-42 (2011).
  • Okamoto, N., Yasukawa, M., Nguyen, C., Kasim, V., Maida, Y., Possemato, R., Shibata, T., Ligon, K. L., Fukami, K., Hahn, W. C., Masutomi, K., Maintenance of tumor initiating cells of defined genetic composition by a complex composed of nucleostemin. Proc. Natl. Acad. Sci.USA 108, 20388-93 (2011).

総説・著書など

  • 飯村忠浩、中根綾子、姫野彰子、杉山真由、山口朗「骨のin vivo 蛍光イメージングの現状と展望」 日本骨形態計測学会雑誌 2011
  • Iimura, T., Sugiyama, M., Watanabe, T., Nakane, A., Makino, Y., Yamaguchi, A., Lighting up skeletal biology by fluorescent imaging. The Journal of Oral Biosciences 2011

~2010

主な代表論文

  • Yamaguchi, H., Yoshida, S., Muroi, E., Kawamura, M., Kouchi, Z., Nakamura, Y., Sakai, R., and Fukami, K. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Iα are required for invadopodia formation in human breast cancer cells. Cancer Sci. 101. 1632-38 (2010)
  • Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S., and Miyawaki, A. Illuminating cell-cycle progression in the developing zebrafish embryo. Proc. Natl. Acad. Sci. USA 106, 20812–20817 (2009)
  • Yamaguchi, H., Takeo, Y., Yoshida, S., Kouchi, Z., Nakamura, Y., Fukami , K. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res. 69. 8594-602 (2009)
  • Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., Imamura, T., Ogawa, M., Masai , H., and Miyawaki, A. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell. 132, 341-343 (2008)
  • Nakamura, Y., Ichinohe, M., Hirata, M., Matsuura, H., Fujiwara, T., Igarashi, T., Nakahara, M., Yamaguchi, H., Yasugi, S., Takenawa T., and Fukami, K., Phospholipase Cδ1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J. 22. 841-849 (2008)
  • Ichinohe, M., Nakamura, Y., Sai, K., Nakahara, M., Yamaguchi, H., and Fukami , K. Lack of phospholipase Cδ1 induces skin inflammation. Biochem. Biophys. Res. Commun. 356, 912-8 (2007)
  • Nakahara, M., Shimozawa, M., Nakamura, Y., Irino, Y., Morita, M., Kudo, K., and Fukami, K. A novel phospholipase C, PLCeta2, is a neuron-specific isozyme J. Biol. Chem. 280, 29128-34 (2005)
  • Kouchi, Z., Shikano, T., Nakamura, Y., Shirakawa, H., Fukami, K., and Miyazaki, S. The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase Cζ J. Biol. Chem. 280, 21015-21 (2005)
  • Hong., He, Watanabe, T., Zhan, X., Huang, C., Schuuring, E., Fukami, K. and Takenawa, T.C. Chandra Kumar, Richard U. Simpson and Hirosi Maruta Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosine II complex and malignant transformation. Mol. Cell. Biol. 18, 3829-3837 (1998)
  • Nakamura, Y., Hamada, Y., Fujiwara, T., Enomoto, H., Hiroe, T., Tanaka, S., Nose, M., Nakahara, M., Yoshida, N., Takenawa, T., and Fukami, K. Phospholipase Cδ1 and δ3 are essential in trophoblast for placental development. Mol. Cell. Biol. 25. 10979-10988 (2005)
  • Irino, Y., Cho, H., Nakamura, Y., Nakahara, M., Furutani, M., Suh, Pann-Ghill., Takenawa, T., and Fukami, K. Phospholipase C delta-type consists of three isozymes; bovine PLCδ2 is a homologue of human/mouse PLCδ4. Biochem. Biophys. Res. Commun. 320, 537-543 (2004)
  • Takenaka, K., Fukami, K., Otsuki, M., Nakamura, Y., Kataoka, Y., Wada, M., Tsuji, K., Nishikawa, S., Yoshida, N., and Takenawa, T. The role of Phospholipase C-L2, a novel phospholipase C like protein that lacks lipase activity, in B cell receptor signaling Mol. Cell. Biol. 23. 7329-7338 (2003)
  • Nakamura, Y., Fukami, K., Yu, H., Takenaka, K., Kataoka, Y., Shirakata, Y., Nishikawa, S., Hashimoto, K., Yoshida, N., and Takenawa, T., Phospholipase Cδ1 is required for skin stem cell lineage commitment. EMBO J. 22. 2981-2991 (2003)
  • Fukami, K., Yoshida, M., Inoue, T., Kurokawa, M., Fissore, A. R., Yoshida, N., Mikoshiba, K., and Takenawa, T. Phospholipase Cδ4 is required for [Ca2+]i mobilization essential for acrosome reaction in sperm. J. Cell Biol. 161. 79-88 (2003)
  • Fukuoka, M., Suetsugu, S., Miki, H., Fukami, K., Endo, T., and Takenawa, T. A novel N-WASP binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J. Cell Biol. 152, 471-482 (2001)
  • Fukami, K., Nakao, K., noue, T., Kataoka, Y., Kurokawa, M., Fissore, A. R., Nakamura, K., Katsuki, M., Mikoshiba, K., Yoshida, N., and Takenawa, T. Reqiurement of phospholipase Cδ4 for the zona pellucida-induced acrosome reaction. Science. 292. 920-923 (2001)
  • Laux, T., Fukami, K., Thelen, M., Golub, T., Frey, D., and Caroni, P., GAP43, MARCKS, and CAP23 modulate PI(4,5)P2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149. 1455-1472 (2000)
  • Hong., He, Watanabe, T., Zhan, X., Huang, C., Schuuring, E., Fukami, K. and Takenawa, T.C. Chandra Kumar, Richard U. Simpson and Hirosi Maruta Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosine II complex and malignant transformation. Mol. Cell. Biol. 18, 3829-3837 (1998)
  • Hay, C. J., Fisette, L. P., Jenkins, H. C., Fukami, K., Takenawa, T., Anderson, A. R., and Martin, F.J. T., ATP-dependent inositide phosphorylation required for Ca2+ -activated secretion. Nature 374, 173-177 (1995)
  • Fukami, K., Furuhashi, K., Inagaki, M., Endo, T., Hatano, S., and Takenawa, T. Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function. Nature 359. 150-152 (1992)
  • Han, Jin-Kwan., Fukami, K., and Nuccitelli. R. Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres. J. Cell Biol. 116. 147-156 (1992)
  • Matsuoka, K., Fukami, K., Nakanishi, O., Kawai, S., and Takenawa, T. Mitogenesis in responce to PDGF and bombesin abolished by microinjection of antibody to PIP2. Science 239. 640-643 (1988)
  • Fukami, K., Matsuoka, K., Nakanishi, O., Yamakawa, A., Kawai, S., and Takenawa, T. Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc. Natl. Acad. Sci. USA 85. 9057-9061 (1988)